"Words cannot begin to express my gratitude toward SPINODYSSEY 2011, and ACS for
funding my project. The pressure is now on us to produce meaningful results".
Metastasis is the major reason for morbidity and mortality of breast cancer patients. Every sequential step in the process of metastasis requires specific sets of genes to be turned on or off. These gene sets are regulated in part through large protein complexes that re-organize the structure of DNA and how it is interacting with associated proteins (chromatin). The current focus of our lab is to characterize the composition and enzyme activity of these chromatin modifying complexes that regulate the process of breast cancer metastasis. These studies will provide the necessary groundwork for the identification of novel targets to enable treatment of metastatic breast cancer.
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